TargetMol

CG 428

Product Code:
 
TAR-T41224
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T41224-1mg1mg£213.00
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TAR-T41224-5mg5mg£428.00
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TAR-T41224-1mL1 mL * 10 mM (in DMSO)£440.00
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TAR-T41224-10mg10mg£597.00
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TAR-T41224-25mg25mg£863.00
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TAR-T41224-50mg50mg£1,179.00
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Quantity:
TAR-T41224-100mg100mg£1,581.00
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Quantity:
TAR-T41224-500mg500mg£3,107.00
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Further Information

Bioactivity:
CG 428 is a potent tropomyosin receptor Ki nase (TRK) Degrader (uSMITETM) (DC50= 0.36 nM). CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide. CG 428 shows selectivity for TRKA over TRKC and TRKB (Kdvalues = 1nM, 4.2 nM and 28 nM, respectively). Inhibits growth of KM12 colon cancer cells (IC50 =2.9 nM) and is bioavailable.
CAS:
2412055-93-5
Formula:
0
Molecular Weight:
0
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
0
Target:
Trk receptor

References

Chen L, et al. Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders. J Med Chem. 2020;63(23):14562-14575.