TargetMol

AC-264613

Product Code:
 
TAR-T4186
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4186-5mg5mg£229.00
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TAR-T4186-10mg10mg£320.00
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TAR-T4186-1mL1 mL * 10 mM (in DMSO)£413.00
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TAR-T4186-25mg25mg£497.00
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Further Information

Bioactivity:
AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.
CAS:
1051487-82-1
Formula:
C19H18BrN3O2
Molecular Weight:
400.276
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
CC(=NNC(=O)[C@@H]1[C@H](CNC1=O)c1ccccc1)c1cccc(Br)c1
Target:
Protease-activated Receptor

References

Cosimi E, et al. Stereoselective Synthesis of ?-Fluoro-?-nitro Thioesters under Organocatalytic Conditions. Org Lett. 2016 Dec 2;18(23):6014-6017 Yamaguchi R, et al. A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53. Cell Biol Int. 2016 Jun;40(6):629-41 Ma JN, et al. The protease activated receptor 2 (PAR2) polymorphic variant F240S constitutively activates PAR2 receptors and potentiates responses to small-molecule PAR2 agonists. J Pharmacol Exp Ther. 2013 Dec;347(3):697-704