TargetMol

Takinib

Product Code:
 
TAR-T4264
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4264-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T4264-5mg5mg£124.00
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TAR-T4264-10mg10mg£172.00
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TAR-T4264-25mg25mg£255.00
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TAR-T4264-50mg50mg£348.00
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This product comes from: United States.
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Further Information

Bioactivity:
Takinib is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).
CAS:
1111556-37-6
Formula:
C18H18N4O2
Molecular Weight:
322.368
Pathway:
MAPK; Apoptosis
Purity:
0.9918
SMILES:
CCCn1c(NC(=O)c2cccc(c2)C(N)=O)nc2ccccc12
Target:
Apoptosis; MAPK

References

Totzke J, et al. Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-? Inhibition for Cancer and Autoimmune Disease. Cell Chem Biol. 2017 Aug 17;24(8):1029-1039. Da Q, Yan Z, Li Z, et al. TAK1 is involved in sodium L-lactate-stimulated p38 signaling and promotes apoptosis. Molecular and Cellular Biochemistry. 2020: 1-10 Da Q, Yan Z, Li Z, et al. TAK1 is involved in sodium L-lactate-stimulated p38 signaling and promotes apoptosis[J]. Molecular and Cellular Biochemistry. 2020: 1-10.