TargetMol

Proguanil hydrochloride

Product Code:
 
TAR-T4382
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4382-5mg5mg£111.00
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TAR-T4382-10mg10mg£119.00
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TAR-T4382-1mL1 mL * 10 mM (in DMSO)£122.00
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TAR-T4382-25mg25mg£152.00
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TAR-T4382-50mg50mg£223.00
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TAR-T4382-100mg100mg£344.00
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TAR-T4382-200mg200mg£508.00
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TAR-T4382-500mg500mg£776.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
CAS:
637-32-1
Formula:
C11H17Cl2N5
Molecular Weight:
290.19
Pathway:
Cell Cycle/Checkpoint; ; Microbiology/Virology; DNA Damage/DNA Repair; Metabolism
Purity:
0.9834
SMILES:
Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
Target:
Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite

References

Gerlinde F. Pl?ger, etal. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride[J]. Journal of Pharmaceutical Sciences, 2018, 163(4):1-21.