TargetMol

LY 303511 hydrochloride

Product Code:
 
TAR-T4423
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4423-1mg1mg£97.00
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TAR-T4423-5mg5mg£132.00
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TAR-T4423-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T4423-10mg10mg£173.00
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TAR-T4423-25mg25mg£282.00
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TAR-T4423-50mg50mg£466.00
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TAR-T4423-100mg100mg£647.00
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Further Information

Bioactivity:
LY303511 (NV-128)is a potent mTOR inhibitor
CAS:
2070014-90-1
Formula:
C19H19ClN2O2
Molecular Weight:
342.82
Pathway:
Membrane transporter/Ion channel; Apoptosis; PI3K/Akt/mTOR signaling
Purity:
0.9671
SMILES:
Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1
Target:
Potassium Channel; TNF; mTOR

References

Tucker-Kellogg L,etal.Reactive oxygen species (ROS) and sensitization to TRAIL-induced apoptosis, in Bayesian network modelling of HeLa cell response to LY303511.Biochem Pharmacol. 2012 Nov 15;84(10):1307-17. Shenoy K,etal.LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors.Cancer Res. 2009 Mar 1;69(5):1941-50. Shi Y,etal.Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP.Bioinformatics. 2013 Feb 1;29(3):347-54.