TargetMol

Tucidinostat

Product Code:
 
TAR-T4481
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4481-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T4481-5mg5mg£117.00
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TAR-T4481-10mg10mg£144.00
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TAR-T4481-25mg25mg£208.00
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TAR-T4481-50mg50mg£293.00
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TAR-T4481-100mg100mg£426.00
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TAR-T4481-200mg200mg£569.00
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TAR-T4481-500mg500mg£864.00
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Further Information

Bioactivity:
Tucidinostat is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9.
CAS:
1616493-44-7
Formula:
C22H19FN4O2
Molecular Weight:
390.418
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
0.9752
SMILES:
Nc1cc(F)ccc1NC(=O)c1ccc(CNC(=O)C=Cc2cccnc2)cc1
Target:
HDAC

References

Ning ZQ, et al. Chidamide (CS055/HBI-8000): a new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicity. Cancer Chemother Pharmacol. 2012 Apr;69(4):901-9. Zha J, Zhong M, Pan G, et al.Stratification and therapeutic potential of ELL in cytogenetic normal acute myeloid leukemia.Gene.2022: 147110.