TargetMol

PF-01247324

Product Code:
 
TAR-T4490
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4490-1mL1 mL * 10 mM (in DMSO)£124.00
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TAR-T4490-5mg5mg£124.00
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TAR-T4490-10mg10mg£160.00
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TAR-T4490-25mg25mg£266.00
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TAR-T4490-50mg50mg£430.00
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TAR-T4490-100mg100mg£611.00
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Further Information

Bioactivity:
PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).
CAS:
875051-72-2
Formula:
C13H10Cl3N3O
Molecular Weight:
330.59
Pathway:
Membrane transporter/Ion channel
Purity:
0.9994
SMILES:
CNC(=O)c1ccc(c(N)n1)-c1cc(Cl)cc(Cl)c1Cl
Target:
Sodium Channel

References

Shields SD, et al. Oral administration of PF-201247324, a subtype-selective Nav1.8 blocker, reverses cerebellar deficits in a mouse model of multiple sclerosis. PLoS One. 2015 Mar 6;10(3):e2019067. Payne CE, et al. A novel selective and orally bioavailable Nav 1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability. Br J Pharmacol. 2015 May;172(10):2654-70.