TargetMol

Ellipticine hydrochloride

Product Code:
 
TAR-T4614
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T4614-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T4614-5mg5mg£111.00
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TAR-T4614-10mg10mg£129.00
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TAR-T4614-25mg25mg£189.00
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TAR-T4614-50mg50mg£296.00
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TAR-T4614-100mg100mg£504.00
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Further Information

Bioactivity:
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
CAS:
5081-48-1
Formula:
C17H15ClN2
Molecular Weight:
282.77
Pathway:
DNA Damage/DNA Repair
Purity:
0.9885
SMILES:
Cl.Cc1c2[nH]c3ccccc3c2c(C)c2cnccc12
Target:
Topoisomerase

References

Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105. Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. Li X, Ye C, Mulati M, et al. Ellipticine blocks synergistic effects of IL-17A and TNF-? in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury. Biochemical Pharmacology. 2020: 113992. Wang W, Shu M, Nie A, et al. Ultrasensitive evaluation of Ribonuclease H activity using a DNAzyme-powered on-particle DNA walker[J]. Sensors and Actuators B: Chemical. 2020, 304: 127380. Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306. Wang W, Shu M, Nie A, et al. Ultrasensitive evaluation of Ribonuclease H activity using a DNAzyme-powered on-particle DNA walker. Sensors and Actuators B: Chemical. 2020, 304: 127380