TargetMol

Demethyleneberberine

Product Code:
 
TAR-T4S0800
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4S0800-1mg1mg£119.00
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TAR-T4S0800-5mg5mg£184.00
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TAR-T4S0800-1mL1 mL * 10 mM (in DMSO)£195.00
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TAR-T4S0800-10mg10mg£230.00
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TAR-T4S0800-25mg25mg£348.00
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TAR-T4S0800-50mg50mg£483.00
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Further Information

Bioactivity:
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1, hypoxia inducible factor α, and inducible nitric oxide synthase, which contributes to oxidative stress and restored sirtuin 1/AMP-activated protein kinase/peroxisome proliferator-activated receptor-γ coactivator-1α pathway-associated fatty acid oxidation in chronic ethanol-fed mice.
CAS:
25459-91-0
Formula:
C19H18NO4
Molecular Weight:
324.355
Pathway:
Immunology/Inflammation; NF-κb; Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling; Angiogenesis
Purity:
0.9854
SMILES:
COc1ccc2cc3-c4cc(O)c(O)cc4CC[n+]3cc2c1OC
Target:
P45; NOS; NF-κB; HIF; AMPK

References

Zhang P1,et al.Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model.J Pharmacol Exp Ther. 2015 Jan;352(1):139-47.