TargetMol

Trifolirhizin

Product Code:
 
TAR-T4S0998
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4S0998-1mg1mg£98.00
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TAR-T4S0998-5mg5mg£134.00
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TAR-T4S0998-10mg10mg£181.00
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TAR-T4S0998-25mg25mg£243.00
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TAR-T4S0998-50mg50mg£356.00
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TAR-T4S0998-100mg100mg£499.00
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Quantity:
TAR-T4S0998-500mg500mg£1,058.00
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Further Information

Bioactivity:
Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Trifolirhizin possesses potential anti-inflammatory and anti-cancer activities.Trifolirhizin shows in vitro inhibitory effects on the growth of human A2780 ovarian and H23 lung cancer cells. Trifolirhizin inhibits acetylcholine mediated airway smooth muscle (ASM) contraction or directly relaxes pre-contracted ASM independent of β 2 -adrenoceptors.
CAS:
6807-83-6
Formula:
C22H22O10
Molecular Weight:
446.408
Pathway:
Proteases/Proteasome; Apoptosis
Purity:
0.9927
SMILES:
OC[C@H]1O[C@@H](Oc2ccc3[C@@H]4Oc5cc6OCOc6cc5[C@@H]4COc3c2)[C@H](O)[C@@H](O)[C@@H]1O
Target:
TNF; Tyrosinase

References

Zhou H, Lutterodt H,et al.Anti-Inflammatory and antiproliferative activities of trifolirhizin, a flavonoid from Sophora flavescens roots.J Agric Food Chem. 2009 Jun 10;57(11):4580-5. Yang N, Liang B, et al.The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contraction.Phytochemistry. 2013 Nov;95:259-267. Aratanechemuge Y, Hibasami H, et al.Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells.Oncol Rep. 2004 Dec;12(6):1183-8. Hyun SK, Lee WH,et al.Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis.Biol Pharm Bull. 2008 Jan;31(1):154-8.