TargetMol

(±)-Praeruptorin A

Product Code:
 
TAR-T4S1419
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4S1419-5mg5mg£116.00
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TAR-T4S1419-10mg10mg£148.00
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TAR-T4S1419-25mg25mg£226.00
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TAR-T4S1419-50mg50mg£303.00
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TAR-T4S1419-100mg100mg£419.00
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Further Information

Bioactivity:
1. Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. 3. Praeruptorin A and praeruptorin C can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.
CAS:
73069-25-7
Formula:
C21H22O7
Molecular Weight:
386.4
Pathway:
Metabolism; MAPK; Membrane transporter/Ion channel; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Purity:
0.9973
SMILES:
CC=C(C)C(=O)OC1C(OC(C)=O)c2c(OC1(C)C)ccc1ccc(=O)oc21
Target:
p38 MAPK; Calcium Channel; Akt

References

Jeongtae Y , Sikwon C , Jun R B , et al. Praeruptorin A inhibits in vitro migration of preosteoclasts and in vivo bone erosion, possibly due to its potential to target calmodulin.[J]. Journal of Natural Products, 2015, 78(4):776-82.