TargetMol

Tetrahydrocoptisine

Product Code:
 
TAR-T4S2063
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4S2063-1mg1mg£106.00
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TAR-T4S2063-5mg5mg£148.00
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TAR-T4S2063-10mg10mg£195.00
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TAR-T4S2063-25mg25mg£281.00
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TAR-T4S2063-50mg50mg£383.00
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TAR-T4S2063-100mg100mg£531.00
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Further Information

Bioactivity:
1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may involve the inhibition of pulmonary inflammatory process. 3. Tetrahydrocoptisine has gastroprotective activity, is attributed to reducing NO production and adjusting the pro-inflammatory cytokine, inhibited neutrophil accumulation and NF-κB expression. 4. Tetrahydrocoptisine is an active anti-inflammatory constituent by inhibition of TNF-α, IL-6 and NO production possibly via down-regulation of NF-κB activation, phospho-ERK1/2 and phospho-p38MAPK signal pathways.
CAS:
7461-02-1
Formula:
C19H17NO4
Molecular Weight:
323.34
Pathway:
MAPK; NF-κb
Purity:
0.98
SMILES:
C1CN2CC3=C(CC2C4=CC5=C(C=C41)OCO5)C=CC6=C3OCO6
Target:
ERK; p38 MAPK; NF-κB

References

Li W , Huang H , Niu X , et al. Tetrahydrocoptisine Protects Rats from LPS-Induced Acute Lung Injury[J]. Inflammation, 2014, 37(6):2106-2115.