TargetMol

Ginkgetin

Product Code:
 
TAR-T4S2126
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4S2126-5mg5mg£167.00
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Quantity:
TAR-T4S2126-1mL1 mL * 10 mM (in DMSO)£195.00
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Further Information

Bioactivity:
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead molecule for development of a therapeutic STAT3 inhibitor. 4. Ginkgetin induces apoptosis in PC-3 cells via activation of caspase 3 and inhibition of survival genes as a potent chemotherapeutic agent for prostate cancer treatment. 5. Ginkgetin has neuroprotective activity against neurological injury induced by MPTP occurs via regulating iron homeostasis, it may provide neuroprotective therapy for Parkinson's disease and iron metabolism disorder related diseases.
CAS:
481-46-9
Formula:
C32H22O10
Molecular Weight:
566.518
Pathway:
JAK/STAT signaling; Neuroscience; Stem Cells; Autophagy; Apoptosis; Immunology/Inflammation; Cytoskeletal Signaling
Purity:
0.9994
SMILES:
COc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(OC)c(c1)-c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(O)cc1
Target:
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy

References

Tang T, Wang X, Qi E, et al. Ginkgetin Promotes M2 Polarization of Microglia and Exert Neuroprotection in Ischemic Stroke via Modulation of PPAR? Pathway. Neurochemical Research. 2022: 1-12 You O H , Kim S H , Kim B , et al. Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23(9):2692-2695. Xiao Y, Cai G P, Feng X, et al.Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.The EMBO Journal.2023: e111762.