TargetMol

Brequinar

Product Code:
 
TAR-T5013
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5013-2mg2mg£103.00
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TAR-T5013-5mg5mg£124.00
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TAR-T5013-1mL1 mL * 10 mM (in DMSO)£130.00
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TAR-T5013-10mg10mg£148.00
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TAR-T5013-25mg25mg£214.00
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TAR-T5013-50mg50mg£284.00
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Quantity:
TAR-T5013-100mg100mg£389.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
CAS:
96187-53-0
Formula:
C23H15F2NO2
Molecular Weight:
375.375
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Metabolism
Purity:
0.9957
SMILES:
Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F
Target:
Virus Protease; Dehydrogenase; DNA/RNA Synthesis

References

Tan Q, Zhang X, Li S, et al.DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis.Free Radical Biology and Medicine.2023 Xu X, et al. In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium. J Immunol. 1998 Jan 15;160(2):846-53. Qing M, et al. Characterization of dengue virus resistance to brequinar in cell culture. Antimicrob Agents Chemother. 2010 Sep;54(9):3686-95. Schnellrath LC, et al. Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture. Int J Antimicrob Agents. 2011 Nov;38(5):435-41.