TargetMol

Zofenopril calcium

Product Code:
 
TAR-T5030
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5030-5mg5mg£116.00
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TAR-T5030-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T5030-10mg10mg£149.00
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TAR-T5030-25mg25mg£246.00
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TAR-T5030-50mg50mg£396.00
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TAR-T5030-100mg100mg£544.00
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Further Information

Bioactivity:
Zofenopril Calcium(SQ26991) is an antioxidant that acts as an angiotensin-converting enzyme inhibitor. ACE Zofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor . Zofenopril promotes the regeneration of peripheral nerve injuries in rat models . Zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR .
CAS:
81938-43-4
Formula:
C44H44CaN2O8S4
Molecular Weight:
897.16
Pathway:
NF-κb; Immunology/Inflammation; Endocrinology/Hormones; Metabolism
Purity:
0.9963
SMILES:
[Ca++].CC(CSC(=O)c1ccccc1)C(=O)N1CC(CC1C([O-])=O)Sc1ccccc1.CC(CSC(=O)c1ccccc1)C(=O)N1CC(CC1C([O-])=O)Sc1ccccc1
Target:
RAAS; Reactive Oxygen Species

References

Dal Bo, L., P. Mazzucchelli, and A. Marzo, Assay of zofenopril and its active metabolite zofenoprilat by liquid chromatography coupled with tandem mass spectrometry. J Chromatogr B Biomed Sci Appl, 2000. 749(2): p. 287-94. Frascarelli, S., et al., Effects of zofenopril on cardiac sarcoplasmic reticulum calcium handling. J Cardiovasc Pharmacol, 2009. 54(5): p. 456-63. Kalender, A.M., et al., Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model. J Brachial Plex Peripher Nerve Inj, 2009. 4: p. 6.