TargetMol

Iguratimod

Product Code:
 
TAR-T5032
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5032-5mg5mg£105.00
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Quantity:
TAR-T5032-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T5032-10mg10mg£119.00
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TAR-T5032-25mg25mg£161.00
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TAR-T5032-50mg50mg£237.00
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Quantity:
TAR-T5032-100mg100mg£287.00
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Further Information

Bioactivity:
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
CAS:
123663-49-0
Formula:
C17H14N2O6S
Molecular Weight:
374.37
Pathway:
Immunology/Inflammation; ; Neuroscience
Purity:
0.9975
SMILES:
CS(=O)(=O)Nc1cc2occ(NC=O)c(=O)c2cc1Oc1ccccc1
Target:
COX

References

Tanaka K, et al. T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase-2 (COX-2) in cultured fibroblasts. Jpn J Pharmacol. 1995 Apr;67(4):305-14. Iguratimod, et al. Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential. J Biol Chem. 2016 Dec 16;291(51):26502-26514. Sun Y, et al. Anti-rheumatic drug iguratimod protects against cancer-induced bone pain and bone destruction in a rat model. Oncol Lett. 2017 Jun;13(6):4849-4856.