TargetMol

Atosiban acetate

Product Code:
 
TAR-T5148
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5148-5mg5mg£124.00
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TAR-T5148-10mg10mg£164.00
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TAR-T5148-1mL1 mL * 10 mM (in DMSO)£180.00
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TAR-T5148-25mg25mg£213.00
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TAR-T5148-50mg50mg£245.00
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TAR-T5148-100mg100mg£297.00
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TAR-T5148-500mg500mg£629.00
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Further Information

Bioactivity:
Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
CAS:
914453-95-5
Formula:
C45H71N11O14S2
Molecular Weight:
1054.25
Pathway:
Endocrinology/Hormones; GPCR/G Protein
Purity:
0.9992
SMILES:
CC(O)=O.CCOc1ccc(C[C@H]2NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)[C@@H](C)CC)[C@@H](C)O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)cc1
Target:
Oxytocin Receptor; Vasopressin Receptor

References

Akerlund M, et al. The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Acta Obstet Gynecol Scand. 1985;64(6):499-504.