TargetMol

(E)-AG 99

Product Code:
 
TAR-T5155
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5155-5mg5mg£95.00
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TAR-T5155-10mg10mg£109.00
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TAR-T5155-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T5155-25mg25mg£131.00
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TAR-T5155-50mg50mg£152.00
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TAR-T5155-100mg100mg£204.00
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This product comes from: United States.
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Further Information

Bioactivity:
AG-99 is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
CAS:
122520-85-8
Formula:
C10H8N2O3
Molecular Weight:
204.18
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
Purity:
0.9967
SMILES:
NC(=O)C(=Cc1ccc(O)c(O)c1)C#N
Target:
EGFR

References

Gazit A, et al. Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J Med Chem. 1996 Dec 6;39(25):4905-11. Yamamoto N, et al. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J Cell Sci. 2006 Nov 15;119(Pt 22):4623-33.