TargetMol

AZ304

Product Code:
 
TAR-T5172
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5172-5mg5mg£108.00
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TAR-T5172-10mg10mg£125.00
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TAR-T5172-25mg25mg£172.00
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TAR-T5172-50mg50mg£237.00
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TAR-T5172-100mg100mg£367.00
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TAR-T5172-200mg200mg£515.00
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This product comes from: United States.
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Further Information

Bioactivity:
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
CAS:
942507-42-8
Formula:
C27H25N5O2
Molecular Weight:
451.53
Pathway:
Autophagy; MAPK; Tyrosine Kinase/Adaptors
Purity:
0.9983
SMILES:
COc1ccc2c(Nc3cc(NC(=O)c4cccc(c4)C(C)(C)C#N)ccc3C)ncnc2c1
Target:
c-Fms; Raf; p38 MAPK; Autophagy

References

Ma R, et al. AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. Br J Cancer. 2018 May;118(11):1453-1463.