TargetMol

SKA-31

Product Code:
 
TAR-T5180
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5180-5mg5mg£115.00
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TAR-T5180-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T5180-10mg10mg£135.00
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TAR-T5180-25mg25mg£201.00
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TAR-T5180-50mg50mg£329.00
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Quantity:
TAR-T5180-100mg100mg£530.00
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Further Information

Bioactivity:
SKA 31 is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).
CAS:
40172-65-4
Formula:
C11H8N2S
Molecular Weight:
200.26
Pathway:
Membrane transporter/Ion channel
Purity:
0.98
SMILES:
Nc1nc2c(ccc3ccccc23)s1
Target:
Potassium Channel

References

Sankaranarayanan A, Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol Pharmacol. 2009 Feb;75(2):281-95. Mishra RC, et al. Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels. J Cardiovasc Pharmacol. 2015 Jul;66(1):118-27. Hasenau AL, et al. Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels. Acta Physiol (Oxf). 2011 Sep;203(1):117-26.