TargetMol

Zacopride hydrochloride

Product Code:
 
TAR-T5336
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5336-1mg1mg£101.00
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TAR-T5336-5mg5mg£142.00
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TAR-T5336-1mL1 mL * 10 mM (in DMSO)£169.00
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TAR-T5336-10mg10mg£189.00
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TAR-T5336-25mg25mg£309.00
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TAR-T5336-50mg50mg£454.00
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TAR-T5336-100mg100mg£624.00
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Further Information

Bioactivity:
Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.
CAS:
101303-98-4
Formula:
C15H21Cl2N3O2
Molecular Weight:
346.25
Pathway:
Neuroscience; GPCR/G Protein; Membrane transporter/Ion channel
Purity:
0.9832
SMILES:
Cl.COc1cc(N)c(Cl)cc1C(=O)NC1CN2CCC1CC2
Target:
Potassium Channel; 5-HT Receptor

References

Liu QH, et al. A novel discovery of IK1 channel agonist: zacopride selectively enhances IK1 current and suppresses triggered arrhythmias in the rat. J Cardiovasc Pharmacol. 2012 Jan;59(1):37-48. Nagakura Y, et al. Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Pharmacol Res. 1999 May;39(5):375-82. Costall B, et al. Zacopride: anxiolytic profile in rodent and primate models of anxiety. J Pharm Pharmacol. 1988 Apr;40(4):302-5. Zhai XW, et al. The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat. PLoS One. 2017 May 18;12(5):e20177600.