TargetMol

Zacopride

Product Code:
 
TAR-T5336L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T5336L-5mg5mg£850.00
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TAR-T5336L-50mg50mg£1,661.00
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Quantity:
TAR-T5336L-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias.
CAS:
90182-92-6
Formula:
C15H20ClN3O2
Molecular Weight:
309.79
Purity:
0.98
SMILES:
COc1cc(N)c(Cl)cc1C(=O)NC1CN2CCC1CC2

References

Bourdin CM, Lebreton J, Math?-Allainmat M, Thany SH. Pharmacological profile of zacopride and new quaternarized fluorobenzamide analogues on mammalian ?7 nicotinic acetylcholine receptor. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3184-8. doi: 10.1016/j.bmcl.2015.05.094. Epub 2015 Jun 4. PubMed PMID: 26087938. Curtis MJ. Activation of IK1 by zacopride: amelioration of left ventricular remodeling, but at what risk? J Cardiovasc Pharmacol. 2014 Oct;64(4):343-4. doi: 10.1097/FJC.0000000000000140. PubMed PMID: 25000479. Liu CF, Liu QH, Liu EL, Zhai XW, Zhang L, Luo TE, Zhang WF, Feng QL, Cui XL, Zhao ZQ, Cao JM, Wu BW. Activation of IK1 channel by zacopride attenuates left ventricular remodeling in rats with myocardial infarction. J Cardiovasc Pharmacol. 2014 Oct;64(4):345-56. doi: 10.1097/FJC.0000000000000127. Retraction in: J Cardiovasc Pharmacol. 2015 Mar;65(3):296. PubMed PMID: 25286360. Zhang L, Liu Q, Liu C, Zhai X, Feng Q, Xu R, Cui X, Zhao Z, Cao J, Wu B. Zacopride selectively activates the Kir2.1 channel via a PKA signaling pathway in rat cardiomyocytes. Sci China Life Sci. 2013 Sep;56(9):788-96. doi: 10.1007/s11427-013-4531-z. Epub 2013 Aug 8. PubMed PMID: 23929001.