TargetMol

TP0463518

Product Code:
 
TAR-T5392
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5392-5mg5mg£109.00
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Quantity:
TAR-T5392-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T5392-10mg10mg£130.00
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TAR-T5392-25mg25mg£169.00
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TAR-T5392-50mg50mg£230.00
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TAR-T5392-100mg100mg£370.00
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Further Information

Bioactivity:
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
CAS:
1558021-37-6
Formula:
C20H18ClN3O6
Molecular Weight:
431.83
Pathway:
Chromatin/Epigenetic; Metabolism
Purity:
0.9943
SMILES:
OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)nc2)C1=O
Target:
HIF/HIF Prolyl-Hydroxylase

References

Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144.