TargetMol

ML216

Product Code:
 
TAR-T5413
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5413-5mg5mg£116.00
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Quantity:
TAR-T5413-1mL1 mL * 10 mM (in DMSO)£124.00
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TAR-T5413-10mg10mg£140.00
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TAR-T5413-25mg25mg£180.00
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TAR-T5413-50mg50mg£224.00
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Quantity:
TAR-T5413-100mg100mg£291.00
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This product comes from: United States.
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Further Information

Bioactivity:
ML-216 is a small molecule inhibitor of BLM helicase (IC50: 1.8 μM). It showed 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s > 50 μM).
CAS:
1430213-30-1
Formula:
C15H9F4N5OS
Molecular Weight:
383.32
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.9683
SMILES:
Fc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C(F)(F)F
Target:
DNA/RNA Synthesis

References

Ma X Y, Zhao J F, Ruan Y, et al.ML216-Induced BLM Helicase Inhibition Sensitizes PCa Cells to the DNA-Crosslinking Agent Cisplatin.Molecules.2022, 27(24): 8790. Ma X Y, Xu H Q, Zhao J F, et al.Discovery of a Novel Bloom?s Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer.International journal of molecular sciences.2022, 23(23): 14798. Nguyen GH, et al. A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem Biol. 2013 Jan 24;20(1):55-62. Rosenthal AS, et al. Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5660-6.