TargetMol

AK-1

Product Code:
 
TAR-T5618
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5618-5mg5mg£111.00
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Quantity:
TAR-T5618-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T5618-10mg10mg£134.00
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TAR-T5618-25mg25mg£202.00
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TAR-T5618-50mg50mg£295.00
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Quantity:
TAR-T5618-100mg100mg£408.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 μM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.
CAS:
330461-64-8
Formula:
C19H21N3O5S
Molecular Weight:
403.45
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.98
SMILES:
[O-][N+](=O)c1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N2CCCCCC2)c1
Target:
Sirtuin

References

Outeiro T F , Kontopoulos E , Altmann S M , et al. Sirtuin 2 Inhibitors Rescue ?-Synuclein-Mediated Toxicity in Models of Parkinson's Disease[J]. Science, 317. Taylor D M , Balabadra U , Xiang Z , et al. A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase[J]. ACS Chemical Biology, 2011, 6(6):540-546.