TargetMol

NG25

Product Code:
 
TAR-T5643
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5643-1mg1mg£138.00
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TAR-T5643-2mg2mg£166.00
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TAR-T5643-5mg5mg£229.00
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TAR-T5643-1mL1 mL * 10 mM (in DMSO)£273.00
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TAR-T5643-10mg10mg£309.00
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TAR-T5643-25mg25mg£551.00
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TAR-T5643-50mg50mg£756.00
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TAR-T5643-100mg100mg£1,018.00
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Quantity:
TAR-T5643-500mg500mg£1,958.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
CAS:
1315355-93-1
Formula:
C29H30F3N5O2
Molecular Weight:
537.587
Pathway:
MAPK
Purity:
0.9946
SMILES:
CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(Oc4ccnc5[nH]ccc45)c3)cc2C(F)(F)F)CC1
Target:
MAPK

References

Fan S, Huang X, Tong H, et al. p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression. European Journal of Pharmacology. 2022: 175277. Wang Z , Zhang H , Shi M , et al. TAK1 inhibitor NG25 enhances doxorubicin-mediated apoptosis in breast cancer cells[J]. Scientific Reports, 2016, 6:32737. Pauls E , Shpiro N , Peggie M , et al. Essential Role for IKK? in Production of Type 1 Interferons by Plasmacytoid Dendritic Cells *[J]. Journal of Biological Chemistry, 2012, 287.