TargetMol

Neferine

Product Code:
 
TAR-T5S1097
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5S1097-5mg5mg£105.00
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TAR-T5S1097-1mL1 mL * 10 mM (in DMSO)£119.00
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TAR-T5S1097-10mg10mg£128.00
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TAR-T5S1097-25mg25mg£182.00
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TAR-T5S1097-50mg50mg£269.00
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TAR-T5S1097-100mg100mg£354.00
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Further Information

Bioactivity:
1. Neferine has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.
CAS:
2292-16-2
Formula:
C38H44N2O6
Molecular Weight:
624.778
Pathway:
Autophagy; Apoptosis; NF-κb
Purity:
0.9975
SMILES:
COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(Oc4cc(C[C@H]5N(C)CCc6cc(OC)c(OC)cc56)ccc4O)cc23)cc1
Target:
Apoptosis; NF-κB; Autophagy

References

Zhang X , Liu Z , Xu B , et al. Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization[J]. European Journal of Pharmacology, 2012, 677(1-3):47-54.