TargetMol

ZM-447439

Product Code:
 
TAR-T6077
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T6077-5mg5mg£107.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T6077-1mL1 mL * 10 mM (in DMSO)£111.00
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Quantity:
TAR-T6077-10mg10mg£119.00
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Quantity:
TAR-T6077-50mg50mg£243.00
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Quantity:
TAR-T6077-100mg100mg£367.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.
CAS:
331771-20-1
Formula:
C29H31N5O4
Molecular Weight:
513.598
Pathway:
Chromatin/Epigenetic; MAPK; Tyrosine Kinase/Adaptors; Apoptosis; Cell Cycle/Checkpoint; Angiogenesis
Purity:
0.9911
SMILES:
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1
Target:
Apoptosis; MEK; Src; Aurora Kinase

References

Georgieva I, et al. Neuroendocrinology. 2010, 91(2), 121-130. Ditchfield C, et al. J Cell Biol. 2003, 161(2), 267-280. Teperek-Tkacz M, et al. Cell Cycle. 2010, 9(23), 4674-4687. Zhang L, et al. J Obstet Gynaecol Res. 2011, 37(6), 591-600.