TargetMol

PFI-1

Product Code:
 
TAR-T6222
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6222-5mg5mg£105.00
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Quantity:
TAR-T6222-1mL1 mL * 10 mM (in DMSO)£108.00
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TAR-T6222-10mg10mg£127.00
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TAR-T6222-25mg25mg£169.00
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Quantity:
TAR-T6222-50mg50mg£230.00
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Quantity:
TAR-T6222-100mg100mg£362.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
PFI-1, a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.
CAS:
1403764-72-6
Formula:
C16H17N3O4S
Molecular Weight:
347.39
Pathway:
Chromatin/Epigenetic; Autophagy; Apoptosis
Purity:
0.9859
SMILES:
COc1ccccc1S(=O)(=O)Nc1ccc2NC(=O)N(C)Cc2c1
Target:
Apoptosis; Epigenetic Reader Domain; Autophagy

References

Picaud S, et al. Cancer Res. 2013, 73(11):3336-46. KE Lines, et al. Endocrine Abstracts, 2013. Fish PV, et al. J Med Chem, 2012, 55(22), 9831-9837. Cheng Z, et al. Clin Cancer Res, 2013, 19(7), 1-12.