TargetMol

U-73122

Product Code:
 
TAR-T6243
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6243-2mg2mg£97.00
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TAR-T6243-5mg5mg£112.00
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TAR-T6243-1mL1 mL * 10 mM (in DMSO)£113.00
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TAR-T6243-10mg10mg£132.00
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TAR-T6243-25mg25mg£180.00
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TAR-T6243-50mg50mg£269.00
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TAR-T6243-100mg100mg£432.00
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Further Information

Bioactivity:
U73122, an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
CAS:
112648-68-7
Formula:
C29H40N2O3
Molecular Weight:
464.65
Pathway:
Apoptosis; Cell Cycle/Checkpoint; Metabolism
Purity:
0.98
SMILES:
COc1ccc2[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CCc2c1)NCCCCCCN1C(=O)C=CC1=O
Target:
Phospholipase; Ferroptosis; Lipoxygenase

References

Wang X, Cai J, Lin B, et al. GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Immunity. 2021, 54(6): 1123-1136. e8. Sudi S, Chin Y Z, Wasli N S, et al. Carpaine Promotes Proliferation and Repair of H9c2 Cardiomyocytes after Oxidative Insults. Pharmaceuticals. 2022, 15(2): 230. Smith RJ, et al. J Pharmacol Exp Ther, 1990, 253(2), 688-697. Ma L, Gong F, Xu J, et al. Uncarboxylated osteocalcin reverses the high glucose?induced inhibition of the osteogenic differentiation of MC3T3E1 cells via the GPRC6A/cAMP/PKA/AMPK signaling pathway. International Journal of Molecular Medicine. 2021 May;47(5):91. doi: 10.3892/ijmm.2021.4924. Epub 2021 Mar 31. Bleasdale JE, et al. J Pharmacol Exp Ther, 1990, 255(2), 756-768. Hou C, et al. J Pharmacol Exp Ther, 2004, 309(2), 697-704. Jin W, et al. Brain Res, 1994, 642(1-2), 237-243. Yule DI, et al. J Biol Chem, 1992, 267(20), 13830-13835. Ma L, Gong F, Xu J, et al. Uncarboxylated osteocalcin reverses the high glucose?induced inhibition of the osteogenic differentiation of MC3T3E1 cells via the GPRC6A/cAMP/PKA/AMPK signaling pathway[J]. International Journal of Molecular Medicine. 2021, 47(5): 1-11 Cui S, Suo N, Yang Y, et al.The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2023: 1-12. Zhu H, Liu X, Wang X, et al.G?? subunit inhibitor decreases DOM-induced head twitch response via the PLC?/IP3/Ca2+/ERK and cAMP signaling pathways.European Journal of Pharmacology.2023: 176038.