TargetMol

GSK-690693

Product Code:
 
TAR-T6285
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6285-1mg1mg£103.00
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Quantity:
TAR-T6285-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T6285-5mg5mg£148.00
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TAR-T6285-10mg10mg£181.00
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TAR-T6285-25mg25mg£295.00
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TAR-T6285-50mg50mg£430.00
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Quantity:
TAR-T6285-100mg100mg£600.00
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This product comes from: United States.
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Further Information

Bioactivity:
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.
CAS:
937174-76-0
Formula:
C21H27N7O3
Molecular Weight:
425.493
Pathway:
Proteases/Proteasome; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Purity:
0.9878
SMILES:
CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N
Target:
Serine Protease; Akt; PKC; AMPK; Autophagy

References

Liu H, Liu Y, Wang H, et al. Geometric Constraints Regulate Energy Metabolism and Cellular Contractility in Vascular Smooth Muscle Cells by Coordinating Mitochondrial DNA Methylation. Advanced Science. 2022: 2203995. Levy DS, et al. Blood, 2009, 113(8), 1723-1729. Altomare DA, et al. Clin Cancer Res, 2010, 16(2), 486-496. Rhodes N, et al. Cancer Res, 2008, 68(7), 2366-2374.