TargetMol

(R)-(-)-Gossypol acetic acid

Product Code:
 
TAR-T6396
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6396-5mg5mg£115.00
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TAR-T6396-1mL1 mL * 10 mM (in DMSO)£151.00
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TAR-T6396-10mg10mg£152.00
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TAR-T6396-25mg25mg£251.00
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Quantity:
TAR-T6396-50mg50mg£396.00
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Quantity:
TAR-T6396-100mg100mg£544.00
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Quantity:
TAR-T6396-500mg500mg£1,099.00
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This product comes from: United States.
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Further Information

Bioactivity:
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID. Phase 2.
CAS:
866541-93-7
Formula:
C32H34O10
Molecular Weight:
578.614
Pathway:
Apoptosis; Autophagy
Purity:
0.995
SMILES:
CC(O)=O.CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O
Target:
BCL; Autophagy

References

Balakrishnan K, et al. Blood, 2009, 113(1), 149-153. Wang G, et al. J Med Chem. 2006, 49(21), 6139-6142. Loberg RD, et al. Neoplasia, 2007, 9(12), 1030-1037. Paoluzzi L, et al. Blood, 2008, 111(11), 5350-5358. Zerp SF, et al. Radiat Oncol, 2009, 23(4), 47.