TargetMol

Ranolazine

Product Code:
 
TAR-T6633
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6633-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T6633-50mg50mg£116.00
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TAR-T6633-100mg100mg£136.00
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TAR-T6633-200mg200mg£171.00
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TAR-T6633-500mg500mg£241.00
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This product comes from: United States.
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Further Information

Bioactivity:
Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the intracellular sodium level.
CAS:
95635-55-5
Formula:
C24H33N3O4
Molecular Weight:
427.545
Pathway:
Membrane transporter/Ion channel; Metabolism
Purity:
0.982
SMILES:
COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1
Target:
Calcium Channel; Sodium Channel

References

Lenaeus M, Gamal El-Din T M, Tonggu L, et al.Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine.Nature Cardiovascular Research.2023: 1-8. Baptista T, et al. Circulation,1996, 93(1), 135-142. Undrovinas AI, et al. J Cardiovasc Electrophysiol,2006, 17 Suppl 1, S169-S177. Song Y, et al. J Cardiovasc Pharmacol,2004, 44(2), 192-199.