TargetMol

Tyrphostin AG 879

Product Code:
 
TAR-T6712
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6712-5mg5mg£105.00
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Quantity:
TAR-T6712-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T6712-10mg10mg£125.00
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TAR-T6712-25mg25mg£197.00
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TAR-T6712-50mg50mg£282.00
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Quantity:
TAR-T6712-100mg100mg£432.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
CAS:
148741-30-4
Formula:
C18H24N2OS
Molecular Weight:
316.46
Pathway:
Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Apoptosis
Purity:
0.98
SMILES:
CC(C)(C)c1cc(C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C
Target:
Apoptosis; EGFR; Trk receptor; HER; PDGFR

References

Rende M, et al. Anticancer Drugs, 2006, 17(8), 929-941. Zhou Y, et al. Cancer Res, 2005, 65(13), 5848-5856. Larsson LI, et al. Cell Mol Life Sci, 2004, 61(19-20), 2624-2631. He H, et al. Cancer J, 2001, 7(3), 191-202. Zhou Y et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 2006 Jan 1;66(1):404-11. He H, et al. Cancer Biol Ther, 2004, 3(1), 96-101.