TargetMol

Dp44mT

Product Code:
 
TAR-T6821
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6821-10mg10mg£102.00
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TAR-T6821-1mL1 mL * 10 mM (in DMSO)£105.00
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TAR-T6821-25mg25mg£122.00
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TAR-T6821-50mg50mg£161.00
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TAR-T6821-100mg100mg£229.00
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TAR-T6821-200mg200mg£278.00
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This product comes from: United States.
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Further Information

Bioactivity:
Dp44mT, a effective iron chelator, has selective antitumor activity.
CAS:
152095-12-0
Formula:
C14H15N5S
Molecular Weight:
285.37
Pathway:
; Apoptosis; Cell Cycle/Checkpoint
Purity:
0.99
SMILES:
CN(C)C(=S)NN=C(c1ccccn1)c1ccccn1
Target:
Apoptosis; Ferroptosis

References

Rao VA, et al. Cancer Res. 2009, 69(3), 948-957. Jansson PJ, et al. J Biol Chem. 2015, 290(15), 9588-9603. Yuan J, et al. Blood. 2004, 104(5), 1450-1458. Yalowich J C , Wu X , Zhang R , et al. The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase II?[J]. Biochemical Pharmacology, 2012, 84(1):52-58. Whitnall M, et al. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6.