TargetMol

PHA-767491 hydrochloride

Product Code:
 
TAR-T6940
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6940-5mg5mg£105.00
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TAR-T6940-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T6940-10mg10mg£119.00
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TAR-T6940-25mg25mg£149.00
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TAR-T6940-50mg50mg£185.00
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TAR-T6940-100mg100mg£259.00
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TAR-T6940-200mg200mg£350.00
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Further Information

Bioactivity:
PHA-767491 is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1.
CAS:
942425-68-5
Formula:
C12H12ClN3O
Molecular Weight:
249.7
Pathway:
Cell Cycle/Checkpoint; Stem Cells; Apoptosis; PI3K/Akt/mTOR signaling
Purity:
0.9992
SMILES:
Cl.O=C1NCCc2[nH]c(cc12)-c1ccncc1
Target:
Apoptosis; GSK-3; CDK

References

Yecies D, et al. Blood, 2010, 115(16), 3304-3313. Montagnoli A, et al. Nat Chem Biol, 2008, 4(6), 357-365.