TargetMol

PLX7904

Product Code:
 
TAR-T6949
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6949-10mg10mgEnquire
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TAR-T6949-50mg50mgEnquire
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TAR-T6949-2mg2mg£94.00
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TAR-T6949-5mg5mg£111.00
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TAR-T6949-1mL1 mL * 10 mM (in DMSO)£114.00
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This product comes from: United States.
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Further Information

Bioactivity:
PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.
CAS:
1393465-84-3
Formula:
C24H22F2N6O3S
Molecular Weight:
512.54
Pathway:
MAPK
Purity:
0.98
SMILES:
CCN(C)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2cnc(nc2)C2CC2)c1F
Target:
Raf

References

Le K, et al. Pigment Cell Melanoma Res. 2013, 26(4):509-517. Zhang C, et al. Nature. 2015, 526(7574):583-586.