TargetMol

Linarin

Product Code:
 
TAR-T6S0653
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6S0653-5mg5mg£109.00
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TAR-T6S0653-10mg10mg£136.00
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TAR-T6S0653-25mg25mg£205.00
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TAR-T6S0653-50mg50mg£273.00
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TAR-T6S0653-100mg100mg£374.00
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This product comes from: United States.
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Further Information

Bioactivity:
1. Linarin (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways. 3. Linarin prevents A beta-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. 4. The piperine significantly enhanced the oral absorption of Linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of Linarin.
CAS:
480-36-4
Formula:
C28H32O14
Molecular Weight:
592.55
Pathway:
Neuroscience; Apoptosis
Purity:
0.9781
SMILES:
COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2o1
Target:
TNF; AChE

References

Jang S A, Hwang Y H, Yang H, et al. Water Extract of Mentha arvensis L. Attenuates Estrogen Deficiency-Induced Bone Loss by Inhibiting Osteoclast Differentiation. Frontiers in Pharmacology. 2021, 12. Kim S J , Cho H I , Kim S J , et al. Protective effect of linarin against d-galactosamine and lipopolysaccharide-induced fulminant hepatic failure[J]. European Journal of Pharmacology, 2014, 738:66-73.