TargetMol

1,5-Isoquinolinediol

Product Code:
 
TAR-T7042
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7042-1mL1 mL * 10 mM (in DMSO)£117.00
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TAR-T7042-5mg5mg£117.00
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TAR-T7042-10mg10mg£140.00
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TAR-T7042-50mg50mg£224.00
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Further Information

Bioactivity:
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.
CAS:
5154-02-9
Formula:
C9H7NO2
Molecular Weight:
161.16
Pathway:
Chromatin/Epigenetic; DNA Damage/DNA Repair
Purity:
0.9943
SMILES:
Oc1cccc2c(O)nccc12
Target:
PARP

References

Davar D, et al. Role of PARP inhibitors in cancer biology and therapy.[J]. Current Medicinal Chemistry, 2012, 19(23). Ruscetti T, et al. Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase[J]. Journal of Biological Chemistry, 1998, 273(23):14461-14467. Banasik M, et al. Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase[J]. Journal of Biological Chemistry, 1992, 267(3):1569-1575.