TargetMol

2-D08

Product Code:
 
TAR-T7379
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7379-5mg5mg£112.00
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TAR-T7379-1mL1 mL * 10 mM (in DMSO)£116.00
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TAR-T7379-10mg10mg£142.00
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TAR-T7379-25mg25mg£222.00
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TAR-T7379-50mg50mg£309.00
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TAR-T7379-100mg100mg£503.00
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Further Information

Bioactivity:
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
CAS:
144707-18-6
Formula:
C15H10O5
Molecular Weight:
270.24
Pathway:
Ubiquitination; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
Oc1ccc(c(O)c1O)-c1cc(=O)c2ccccc2o1
Target:
E1/E2/E3 Enzyme; TAM Receptor

References

Kim Y S , Keyser S G L , Schneekloth J S . Synthesis of 2?,3?,4?-trihydroxyflavone (2-D08), an Inhibitor of Protein Sumoylation[J]. Bioorganic & medicinal chemistry letters, 2014, 24(4). Marsh D T , Das S , Ridell J , et al. Structure-activity relationships for flavone interactions with amyloid ? reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08).[J]. Bioorganic & Medicinal Chemistry, 2017, 25(14). Kim Y , Nagy K , Keyser S , et al. An Electrophoretic Mobility Shift Assay Identifies a Mechanistically Unique Inhibitor of Protein Sumoylation[J]. Chemistry & Biology, 2013, 20(4):604-613.