TargetMol

PD 128907

Product Code:
 
TAR-T7553L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7553L-5mg5mg£1,091.00
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TAR-T7553L-50mg50mg£2,143.00
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TAR-T7553L-100mg100mg£2,801.00
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Further Information

Bioactivity:
PD 128907 is a potent and selective agonist of dopamine D2 and D3 receptors. It is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release, as well as release of other neurotransmitters.
CAS:
123594-64-9
Formula:
C14H19NO3
Molecular Weight:
249.31
Purity:
0.98
SMILES:
[H][C@]12COc3ccc(O)cc3[C@]1([H])OCCN2CCC

References

Zapata A, Shippenberg TS. Lack of functional D2 receptors prevents the effects of the D3-preferring agonist (+)-PD 128907 on dialysate dopamine levels. Neuropharmacology. 2005 Jan;48(1):43-50. PubMed PMID: 15617726. Xu P, Huang S, Mao C, et al. Structures of the human dopamine D3 receptor-Gi complexes. Molecular Cell. 2021 Mar 18;81(6):1147-1159.e4. doi: 10.1016/j.molcel.2021.01.003. Epub 2021 Feb 5. Xu P, Huang S, Mao C, et al. Structures of the human dopamine D3 receptor-Gi complexes[J]. Molecular Cell. 2021 Zhang M, Ballard ME, Unger LV, Haupt A, Gross G, Decker MW, Drescher KU, Rueter LE. Effects of antipsychotics and selective D3 antagonists on PPI deficits induced by PD 128907 and apomorphine. Behav Brain Res. 2007 Aug 22;182(1):1-11. Epub 2007 May 1. PubMed PMID: 17570538. Fukunaga Y, Uchida T, Ito Y, Matsumoto K, Katsuki T. Ru(CO)-salen-catalyzed synthesis of enantiopure aziridinyl ketones and formal asymmetric synthesis of (+)-PD 128907. Org Lett. 2012 Sep 7;14(17):4658-61. doi: 10.1021/ol302095r. Epub 2012 Aug 28. PubMed PMID: 22928558. Kotani M, Enomoto T, Murai T, Nakako T, Iwamura Y, Kiyoshi A, Matsumoto K, Matsumoto A, Ikejiri M, Nakayama T, Ogi Y, Ikeda K. The atypical antipsychotic blonanserin reverses (+)-PD-128907- and ketamine-induced deficit in executive function in common marmosets. Behav Brain Res. 2016 May 15;305:212-7. doi: 10.1016/j.bbr.2016.02.031. Epub 2016 Mar 9. PubMed PMID: 26970575.