TargetMol

VTP-27999 TFA

Product Code:
 
TAR-T7668
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7668-1mg1mg£106.00
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TAR-T7668-5mg5mg£149.00
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TAR-T7668-10mg10mg£201.00
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TAR-T7668-25mg25mg£309.00
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TAR-T7668-50mg50mg£495.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
VTP-27999 TFA is an inhibitor of Renin (IC50 : 0.47 nM).
CAS:
1013937-63-7
Formula:
C28H42ClF3N4O7
Molecular Weight:
639.11
Pathway:
Endocrinology/Hormones
Purity:
0.9972
SMILES:
OC(=O)C(F)(F)F.CNC(CNC(=O)N1CCCC(C1)C(OCCNC(=O)OC)c1cccc(Cl)c1)CC1CCCOC1
Target:
RAAS

References

Krop M , Lu X , Verdonk K , et al. New Renin Inhibitor VTP-27999 Alters Renin Immunoreactivity and Does Not Unfold Prorenin[J]. Hypertension, 2013, 61(5):1075-1082. Ishchenko A , Liu Z , Lindblom P , et al. Structure-Based Design Technology Contour and Its Application to the Design of Renin Inhibitors[J]. Journal of Chemical Information and Modeling, 2012, 52(8):2089-2097.