TargetMol

ONO-7475

Product Code:
 
TAR-T8327
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8327-1mg1mg£116.00
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TAR-T8327-5mg5mg£182.00
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TAR-T8327-1mL1 mL * 10 mM (in DMSO)£209.00
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TAR-T8327-10mg10mg£249.00
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TAR-T8327-25mg25mg£373.00
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TAR-T8327-50mg50mg£519.00
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Quantity:
TAR-T8327-100mg100mg£702.00
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This product comes from: United States.
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Further Information

Bioactivity:
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
CAS:
1646839-59-9
Formula:
C32H26N4O6
Molecular Weight:
562.582
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.9833
SMILES:
COc1cc2nccc(Oc3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccccc5)c4=O)nc3)c2cc1OC
Target:
Trk receptor; TAM Receptor

References

Okura N, et al. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non-Small Lung Cancer.Clin Cancer Res. 2020 Jan 17. Ruvolo PP, et al. Anexelekto/MER tyrosine kinase?inhibitor?ONO-7475?arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms.Haematologica.?2017 Dec;102(12):2048-2057.