TargetMol

Crizotinib hydrochloride

Product Code:
 
TAR-T8399
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8399-5mg5mg£95.00
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TAR-T8399-10mg10mg£109.00
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TAR-T8399-1mL1 mL * 10 mM (in DMSO)£114.00
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TAR-T8399-25mg25mg£131.00
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TAR-T8399-50mg50mg£152.00
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TAR-T8399-100mg100mg£183.00
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TAR-T8399-200mg200mg£210.00
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TAR-T8399-500mg500mg£262.00
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This product comes from: United States.
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Further Information

Bioactivity:
Crizotinib hydrochloride is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
CAS:
1415560-69-8
Formula:
C21H23Cl3FN5O
Molecular Weight:
486.8
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; Autophagy; Immunology/Inflammation
Purity:
0.9967
SMILES:
Cl.C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Target:
c-Met/HGFR; ROS; ALK; Autophagy; ROS Kinase

References

Christensen JG, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther. 2007, 6(12 Pt 1), 3314-3322. Cui JJ, et al. Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem. 2011 Sep 22;54(18):6342-63.