TargetMol

IQ-3

Product Code:
 
TAR-T8477
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8477-1mg1mg£98.00
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TAR-T8477-5mg5mg£132.00
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TAR-T8477-1mL1 mL * 10 mM (in DMSO)£141.00
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TAR-T8477-10mg10mg£164.00
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TAR-T8477-25mg25mg£256.00
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TAR-T8477-50mg50mg£367.00
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TAR-T8477-100mg100mg£511.00
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Further Information

Bioactivity:
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.
CAS:
312538-03-7
Formula:
C20H11N3O3
Molecular Weight:
341.326
Pathway:
MAPK
Purity:
0.98
SMILES:
O=C(ON=C1c2ccccc2-c2nc3ccccc3nc12)c1ccco1
Target:
JNK

References

Schepetkin I A , Kirpotina L N , Khlebnikov A I , et al. Identification and Characterization of a Novel Class of c-Jun N-terminal Kinase Inhibitors[J]. Molecular Pharmacology, 2012, 81(6):832-845.