TargetMol

NSAH

Product Code:
 
TAR-T8800
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8800-5mg5mg£122.00
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TAR-T8800-1mL1 mL * 10 mM (in DMSO)£127.00
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TAR-T8800-10mg10mg£161.00
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TAR-T8800-25mg25mg£254.00
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TAR-T8800-50mg50mg£369.00
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TAR-T8800-100mg100mg£550.00
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Quantity:
TAR-T8800-500mg500mg£1,083.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
NSAH is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.
CAS:
1099592-35-4
Formula:
C18H14N2O3
Molecular Weight:
306.3
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.9959
SMILES:
O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O
Target:
DNA/RNA Synthesis

References

Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246. Tessianna A , Misko, Yi-Ting, et al. Structure-guided design of anti-cancer ribonucleotide reductase inhibitors.[J]. Journal of enzyme inhibition and medicinal chemistry, 2019.