TargetMol

Locostatin

Product Code:
 
TAR-T8823
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8823-5mg5mg£102.00
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Quantity:
TAR-T8823-1mL1 mL * 10 mM (in DMSO)£105.00
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Quantity:
TAR-T8823-10mg10mg£118.00
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TAR-T8823-25mg25mg£161.00
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TAR-T8823-50mg50mg£209.00
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Quantity:
TAR-T8823-100mg100mg£270.00
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Quantity:
TAR-T8823-200mg200mg£370.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Locostatin is a potent and cell permeable inhibitor of Raf kinase inhibitor protein (RKIP)/Raf1 kinase interaction and an inhibitor of cell migration.
CAS:
133812-16-5
Formula:
C14H15NO3
Molecular Weight:
245.278
Pathway:
MAPK
Purity:
0.9984
SMILES:
CC=CC(=O)N1C(Cc2ccccc2)COC1=O
Target:
Raf

References

Junji, Yuzi, Qiu, et al. Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice.[J]. Digestive diseases and sciences, 2019. A M J , Stefania Greco A , B M S I A , et al. Locostatin, a disrupter of Raf kinase inhibitor protein, inhibits extracellular matrix production, proliferation, and migration in human uterine leiomyoma and myometrial cells[J]. Fertility and Sterility, 2016, 106( 6):1530-1538. Ye J J, Wei S L, Wei Y Y, et al.RKIP suppresses the influenza A virus?induced airway inflammatory response via the ERK/MAPK pathway.International Journal of Molecular Medicine.2023, 51(1): 1-14.