TargetMol

ICCB-19 hydrochloride

Product Code:
 
TAR-T8931L
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8931L-5mg5mg£108.00
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Quantity:
TAR-T8931L-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T8931L-10mg10mg£135.00
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Quantity:
TAR-T8931L-25mg25mg£201.00
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Quantity:
TAR-T8931L-50mg50mg£269.00
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Quantity:
TAR-T8931L-100mg100mg£367.00
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Quantity:
TAR-T8931L-200mg200mg£511.00
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Quantity:
TAR-T8931L-500mg500mg£768.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
CAS:
1803605-68-6
Formula:
C12H22ClN3OS
Molecular Weight:
291.84
Pathway:
; Autophagy; NF-κb; Apoptosis
Purity:
0.9923
SMILES:
Cl.O=C(CSC1=NCCN1)NC1CCCCCC1
Target:
Apoptosis; Autophagy; RIP kinase

References

Xu D , Zhao H , Jin M , et al. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis[J]. Nature, 2020, 587(7832):1-6.