TargetMol

BTYNB

Product Code:
 
TAR-T9033
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9033-1mg1mg£98.00
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TAR-T9033-5mg5mg£135.00
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TAR-T9033-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T9033-10mg10mg£182.00
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TAR-T9033-25mg25mg£302.00
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TAR-T9033-50mg50mg£430.00
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TAR-T9033-100mg100mg£599.00
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TAR-T9033-200mg200mg£824.00
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TAR-T9033-500mg500mg£1,179.00
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Further Information

Bioactivity:
MDK6620?is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA).?MDK6620?downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB).?It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association
CAS:
304456-62-0
Formula:
C12H9BrN2OS
Molecular Weight:
309.18
Pathway:
NF-κb; Cell Cycle/Checkpoint;
Purity:
0.9991
SMILES:
NC(=O)c1ccccc1N=Cc1ccc(Br)s1
Target:
c-Myc; NF-κB

References

Mahapatra L , Andruska N , Mao C , et al. A Novel IMP1 Inhibitor, BTYNB, Targets c-Myc and Inhibits Melanoma and Ovarian Cancer Cell Proliferation[J]. Translational Oncology, 2017, 10(5):818-827. Simon M , Nadine B , Bianca B , et al. The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer[J]. Nucleic Acids Research, 2020(15):15.