TargetMol

NAcM-OPT HCl(2089293-61-6 free base)

Product Code:
 
TAR-T9140
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9140-2mg2mg£96.00
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TAR-T9140-5mg5mg£108.00
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TAR-T9140-10mg10mg£138.00
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TAR-T9140-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T9140-25mg25mg£192.00
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TAR-T9140-50mg50mg£273.00
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TAR-T9140-100mg100mg£401.00
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TAR-T9140-500mg500mg£855.00
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Further Information

Bioactivity:
NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
CAS:
2416146-10-4
Formula:
C23H30Cl3N3O
Molecular Weight:
470.86
Pathway:
Metabolism
Purity:
0.9893
SMILES:
Cl.CCCCN1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Target:
NEDD8

References

Hammill JT, et al. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61(7):2694-2706.